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CD138+ Metastatic Lobular Carcinoma Mimicking a Plasma Cell Neoplasm

Author: Margaux Canevari, DO, 10/25/2019
Category: Laboratory Hematology > Non-hematopoietic malignancies involving the blood or bone marrow > Metastatic Carcinoma
Published Date: 10/30/2019

An 85 year old woman with a past medical history of endometrial serous adenocarcinoma presented with thrombocytopenia and macrocytic anemia, which prompted clinical work up for a myelodysplastic syndrome. The set of images includes the touch prep and core biopsy of a plasmacytoid metastatic lobular carcinoma of the breast to the bone marrow. Of note, CD138 is not specific for plasma cells and can highlight epithelial neoplasms as shown here.