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Myeloid and erythroid vacuolation in acquired copper deficiency secondary to zinc supplementation and jejunostomy feeds 2

Myeloid and erythroid vacuolation in acquired copper deficiency secondary to zinc supplementation and jejunostomy feeds 2
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Author:  Gemma Crighton, MSc, FRACP, FRCPA, MBChB; Song Chen, MBBS, FRCPA
Category:  Red Cell: Disorders of Iron Metabolism and Heme Synthesis > Sideroblastic anemias > Acquired/Reversible Sideroblastic Anemias > Copper deficiency
Published Date:  04/16/2026

Bone marrow aspirate (x40 magnification - Wright-Giemsa stain). Erythropoiesis is left shifted with prominent cytoplasmic vacuolation of proerythroblasts and dyserythropoiesis of late erythroblasts. Myelopoieis is reduced and left-shifted with prominent cytoplasmic vacuolation of promyelocytes and myelocytes.


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