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Lymph node biopsy (Image 2) morphologically shows effacement of the nodal architecture with very occasional pale proliferation centers (Image 2A, hematoxylin and eosin, original magnification X100).  There are also areas of necrosis with granulocytic infiltration and adjacent to these are cells with nuclear inclusions, showing features of margination, multinucleation and molding (Image 2B, original magnification X400; 2C original magnification X1000). The small lymphocytes are positive for CD20 (original magnification X100), CD5 and negative for CD3 (original magnification X100). HSV immunostaining (original magnification X400) highlights the nuclear inclusion. Both flow-cytometry and biopsy findings confirm a diagnosis of SLL with superimposed HSV infection.