Bone Marrow Necrosis 5

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Bone Marrow Necrosis 5

#00063494

Author: Krunal Shah, DNB
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Precursor Lymphoid Neoplasms > B-lymphoblastic leukemia/lymphoma
Published Date: 04/01/2021

The bone marrow biopsy is hypercellular and the marrow spaces are replaced with blast cells.
The blasts are large in size with high N:C ratio, scant cytoplasm, hyperchromatic nuclei with inconspicuous nucleoli. There are areas of coagulative necrosis with presence of faint cell outlines and loss of nuclei. There is marked paucity of erythropoeisis, myelopoeisis and megakaryopoeisis in the sections examined.
The blast shows strong membranous positivity for CD10
CD 34 positive stainig
focal nuclear positivity for TDT.

Diagnosis- Acute leukemia with focal areas of Coagulative necrosis.

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