Erythrophagocytosis in B cell acute Lymphoblastic Leukemia.

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Erythrophagocytosis in B cell acute Lymphoblastic Leukemia.

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Author: Dr. Vinoth kumar G, MD; Dr.Anu Korula DM,; Dr. Nancy Beryl Janet PhD,; Dr. Arpana Palle MD,; Dr. Sukesh C Nair MD
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Precursor Lymphoid Neoplasms > B-lymphoblastic leukemia/lymphoma
Published Date: 12/28/2020

A 38 years old gentleman presented with headache and vomiting. Blood count showed anemia (Hb: 5.8 g/dl), thrombocytopenia (27,000/cumm) and leucocytosis (44,900/cumm). Peripheral smear showed 94% blasts. An occasional blast exhibited erythrophagocytosis. Bone marrow and immunophenotyping consistent with B cell - Acute lymphoblastic leukaemia. Karyotyping showed 46,XY,del(9)(p21)[11]/46,XY,+1,der(1;9)(q10;p10)[8]/46,XY[2]. RT-PCR negative for BCR-ABL. FISH negative for TEL-AML, MLL-AF4 & E2A-PBX.

Erythrophagocytosis is mostly seen in acute myeloid leukemia, particularly with monocytic differentiation. Very few cases of erythrophagocytosis were reported in acute lymphoblastic leukaemia. Clinical significance of erythrophagocytosis by leukemic blasts is unknown.

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