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Dapsone is being used in clinical practice as antibiotic, antiparasitic. It is also known to have anti-inflammatory properties. This drug is may cause mild chronic oxidative haemolysis at doses of 50 to 100 mg per day. 

The amine metabolites of dapsone causes oxidation of heme iron, which results in acquired methemoglobinemia and hemoglobin denaturation which precipitate as Heinz bodies in red blood cells. Heinz bodies are seen as small, round, basophilic deposits on supravital stains. These are typically located near the inner membrane of the red blood cell. These precipitates are removed by splenic macrophages, thus forming bite cells. 

The peripheral smear in oxidative Haemolysis shows irregularly contracted red blood cells, blister cells, bite cells and spherocytes.