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Mantle cell lymphoma with mantle zone pattern-3

Mantle cell lymphoma with mantle zone pattern-3
#00062365
Author: Maryam Asif; Daniel Arber; Girish Venkataraman, MD
Category: Lymphoma: Mature B-cell and Plasma cell Neoplasms > Mantle cell Lymphoma
Published Date: 06/11/2019

Cyclin D1 is positive in mantle zones. The translocation t(11;14)(q13;q32) leads to overexpression of cyclin D1 and is considered the primary oncogenic event in mantle cell lymphomas.