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T-ALL: del(1q) & t(5;10)

T-ALL: del(1q) & t(5;10)
#00061448
Author: Dr. Ganesh P. Pujari, Dr. Sharat Damodar - India
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Precursor Lymphoid Neoplasms > T-lymphoblastic leukemia/lymphoma
Published Date: 05/22/2018

The ON (overnight) unstimulated bone marrow cultures, on conventional karyotyping, show del(1q) and t(5;10). Both these abnormalities have not been reported in T-cell ALL so far.

[Ref: https://cgap.nci.nih.gov/Chromosomes/Mitelman]. Hence, it's impact on outcome cannot be commented upon. Karyotype reported was:

45,XY,del(1)(q21q25),-5,der(10)t(5;10)(q10;q10)