IgG4 related lymphadenopathy

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IgG4 related lymphadenopathy

#00060523

Author: Girish Venkataraman, MD, MBBS; Yanxia (Cathy) Li
Category: Infectious Disease > Viruses > Human Immunodeficiency Syndrome > Lymphoid aggregates
Published Date: 03/13/2016

Patient with recurrent adenopathy with concern for lymphoma. Increased intrafollicular IgG4+ plasma cells are present. This case otherwise showed follicular hyperplasia with polyclonal plasma cells.

Such intrafollicular plasma cells are often seen in cases of IgG4-related lymphadenopathy. The current criteria requires >100 IgG4+ plasma cells/HPF and >40% IgG4+ fraction within all IgG+ plasma cells for establishing the diagnosis of IgG4-related lymphadenopathy.

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